Monthly Archives: January 2014


Combination Varenicline and Bupropion SR for Tobacco-Dependence Treatment in Cigarette Smokers:  A Randomized Trial

Jon O. Ebbert et al JAMA. 2014;3112:155-163. doi:10.1001/jama.2013.283185. Abstract Importance  Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. Objective  To determine efficacy and safety of varenicline and bupropion sustained-release (SR; combination therapy) compared with varenicline (monotherapy) in cigarette smokers. Design, Setting, and Participants  Randomized, blinded, placebo-controlled multicenter clinical trial with a 12-week treatment […]


COPD and Safety of Tiotropium: Disproving a Negative?

Video of Andy Shorr, from George Washington University in Washington, DC, with the Pulmonary and Critical Care literature update. I want to highlight an article[1] that was in the October 17 issue of the New England Journal of Medicine. This is the TIOSPIR study, a large randomized controlled trial looking […]


Scientists discover odour receptors in lungs

Scientists have found that our lungs have odour receptors, suggesting that nose is not the only organ in the body to have a sense of smell. Unlike the receptors in the nose, which are located in the membranes of nerve cells, the ones in the lungs are in the membranes […]