COPD Respiratory / Asthma Pulmonary System Depression Depression decreases adherence to COPD maintenance medications

Article: Adherence to Maintenance Medications among Older Adults with Chronic Obstructive Pulmonary Disease: The Role of Depression, ennifer S. Albrecht, Yujin Park, Peter Hur, Ting-Ying Huang, Ilene Harris, Giora Netzer, Susan W Lehmann, Patricia Langenberg, Bilal Khokhar, Yu-Jung Wei, Patience Moyo, and Linda Simoni-Wastila, Annals of the American Thoracic Society, doi: 10.1513/AnnalsATS.201602-136OC, published online 22 June 2016.

Rationale: Among individuals with Chronic Obstructive Pulmonary Disease (COPD), depression is one of the most common yet under-recognized and under-treated comorbidities. Although depression has been associated with reduced adherence to maintenance medications used in other conditions, such as diabetes, little research has assessed depression’s role in COPD medication use and adherence. Objectives: The objective of this study was to assess the impact of depression on COPD maintenance medication adherence among a nationally representative sample of Medicare beneficiaries newly diagnosed with COPD. Methods: We used a 5% random sample of Medicare administrative claims data to identify beneficiaries diagnosed with COPD between 2006 and 2010. We included beneficiaries with two years of continuous Medicare Parts A, B, and D coverage and at least two prescription fills for COPD maintenance medications following COPD diagnosis. We searched for prescription fills for inhaled corticosteroids, long-acting β-agonists, and long-acting anticholinergics and calculated adherence starting at the first fill. We modelled adherence to COPD maintenance medications as a function of new episodes of depression using generalized estimated equations. Measurements and Main Results: Our primary outcome was adherence to COPD maintenance medications, measured as proportion of days covered (PDC). The exposure measure was depression. Both COPD and depression were assessed using diagnostic codes in Part A and B data. Covariates included sociodemographics, as well as clinical markers, including comorbidities, COPD severity, and depression severity. Of 31,033 beneficiaries meeting inclusion criteria, 6,227 (20%) were diagnosed with depression following COPD diagnosis. Average monthly adherence to COPD maintenance medications was low, peaking at 57% in the month following first fill and decreasing to 35% within six months. In our adjusted regression model, depression was associated with decreased adherence to COPD maintenance medications (OR 0.93; 95% CI 0.89, 0.98). Conclusions: New episodes of depression decreased adherence to maintenance medications used to manage COPD among older adults. Clinicians who treat older adults with COPD should be aware of the development of depression, especially during the first six months following COPD diagnosis, and monitor patients’ adherence to prescribed COPD medications to ensure best clinical outcomes.

Commentary: This study is saying that COPD patients who are depressed are less likely to keep up with their COPD medications. So two messages here for patients: a) if you are depressed seek help b) it is vital for your COPD that you keep on taking your medication (inhalers) every day without fail.

As we know that so many inhalers are prescribed but not taken, this is one thing that could be done to increase compliance and reduce exacerbations. Look out for the COPD patient who is depressed.


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