Smoking Sessation

Combination Varenicline and Bupropion SR for Tobacco-Dependence Treatment in Cigarette Smokers:  A Randomized Trial

Jon O. Ebbert et al JAMA. 2014;3112:155-163. doi:10.1001/jama.2013.283185. Abstract Importance  Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. Objective  To determine efficacy and safety of varenicline and bupropion sustained-release (SR; combination therapy) compared with varenicline (monotherapy) in cigarette smokers. Design, Setting, and Participants  Randomized, blinded, placebo-controlled multicenter clinical trial with a 12-week treatment […]